Chemically, it is a carboxylic acid, which means that its structure contains a carboxyl group (COOH). cannabidiolic acid: ChEBI ID CHEBI:3359: Definition A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a 3-p-mentha-1,8-dien-3-yl (limonene) group. Another small, but important fragment is that at m/z 285.1481 (F2), which corresponds to the breakage between the bonds at C4-C5 and C3-C4 atoms. CBDa is a cannabinoid and chemical compound stored in the glandular trichomes found in the buds, stems, and leaves of the marijuana and hemp plants. Cannabidiolic‐acid (CBDA) synthase is the enzyme that catalyzes oxidative cyclization of cannabigerolic‐acid into CBDA, the dominant cannabinoid constituent of the fiber‐type Cannabis sativa.We cloned a novel cDNA encoding CBDA synthase by reverse transcription and polymerase chain reactions with degenerate and gene‐specific primers. Cannabidiolic acid Structure. In place of plant-derived CBDA, investigators used cannabidiolic acid methyl ester, a synthetic version of the cannabinoid. The purest form of THCa and CBDa concentrates have a crystalline structure. Cannabigerolic acid (CBGA), the precursor to all natural cannabinoids, is cyclized into tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) by THCA and CBDA synthase, respectively. Although most cannabinoids bind directly with either the CB1 or CB2 receptors, CBDA does not work that way. CBD is obtained through non-enzymatic decarboxylation from the acidic form of the cannabinoid, this reaction taking … Close. When heat is applied to CBDA in a process called decarboxylation, it converts to CBD. The corresponding MS-MS spectrum is shown in Fig. The final products of THC and CBD are formed via decarboxylation of these acidic forms. The protonated molecule [M + H] + is 359.2217. Cannabidiolic acid can also be extracted from cannabis plants classified as hemp. Stars This entity has been manually annotated by the ChEBI Team. Cannabidiolic acid (CBDA) is a cannabinoid acid naturally produced in cannabis plants, most commonly found in raw hemp and marijuana plants. Information on EC 1.21.3.8 - cannabidiolic acid synthase for references in articles please use BRENDA:EC1.21.3.8 1244-58-2 - WVOLTBSCXRRQFR-DLBZAZTESA-N - Cannabidiolic acid - Similar structures search, synonyms, formulas, resource links, and other chemical information. Cannabidiolic acid is the carboxylated form of CBD. Systematic / IUPAC Name: 2,4-Dihydroxy-3-[(1R,6R)-6-isopropenyl-3-methyl-2-cyclohexen-1-yl]-6-pentylbenzoic acid ... Cannabidiolic acid mass spectral data can be found in a separate interface. Otherwise known as cannabidiolic acid synthase, this is a catalyst of cannabigerolic acid. It interacts with the endocannabinoid system by inhibiting the … Cannabidiolic Acid. CBDA is the acidic form of CBD, meaning CBDA is the precursor to CBD. The data are manually curated and of the highest quality. Cannabidiolic acid, or CBDA, is one of the many compounds found in cannabis plants. We continue our Cannabinoids Explained series with another compound that exists in the Cannabis sativa plant and seems to have important nutritive benefits: CBD-a.. CBD-a or CBD-acid is the main form in which CBD exists in the cannabis plant, along with THC-a (THC-acid). During a 2018 study, researchers examined CBDA’s antidepressant properties in animal studies investigating two models of depression. 4.This type of acids experiment a rapid water loss of 18 units, leading to the ion at m/z 341.2105 (F1). Evidence is equally compelling for a synthetic compound with a similar structure. When exposed to high temperatures, this chemical compound breaks down to hydrogen, carbon dioxide, and cannabidiol (CBD). 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